Table 1.
Core enrichment gene list of GSEA for mitochondrial genes in female mice.
| Gene symbol | Gene title | Rank in gene list | Rank metric score | Enrichment score | |
|---|---|---|---|---|---|
| 1 | HMGCS2 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) | 37 | 0.274 | 0.0158 |
| 2 | MAOB | monoamine oxidase B | 39 | 0.272 | 0.0332 |
| 3 | COX6B2 | cytochrome c oxidase subunit VIb polypeptide 2 (testis) | 48 | 0.261 | 0.0495 |
| 4 | HSPA1B | heat shock 70 kDa protein 1B | 63 | 0.244 | 0.0645 |
| 5 | UCP3 | uncoupling protein 3 (mitochondrial, proton carrier) | 70 | 0.237 | 0.0794 |
| 6 | ALAS2 | aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia) | 206 | 0.175 | 0.0843 |
| 7 | BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease) | 222 | 0.172 | 0.0946 |
| 8 | DUT | dUTP pyrophosphatase | 311 | 0.159 | 0.1007 |
| 9 | HTRA2 | HtrA serine peptidase 2 | 313 | 0.158 | 0.1107 |
| 10 | ME3 | malic enzyme 3, NADP(+)-dependent, mitochondrial | 431 | 0.145 | 0.1146 |
| 11 | GSTZ1 | glutathione transferase zeta 1 (maleylacetoacetate isomerase) | 575 | 0.134 | 0.1165 |
| 12 | ACOT2 | acyl-CoA thioesterase 2 | 647 | 0.13 | 0.1215 |
| 13 | PCCB | propionyl Coenzyme A carboxylase, beta polypeptide | 660 | 0.13 | 0.1293 |
| 14 | TIMMDC1 | Translocase of inner mitochondrial membrane domain-containing protein 1 | 795 | 0.124 | 0.1309 |
| 15 | RAF1 | v-raf-1 murine leukemia viral oncogene homolog 1 | 851 | 0.121 | 0.1361 |
| 16 | TMEM143 | transmembrane protein 143 | 880 | 0.12 | 0.1425 |
| 17 | NME4 | non-metastatic cells 4, protein expressed in | 920 | 0.119 | 0.1483 |
| 18 | ACP6 | acid phosphatase 6, lysophosphatidic | 975 | 0.116 | 0.1532 |
| 19 | FXN | frataxin | 1014 | 0.114 | 0.1587 |
| 20 | CRY1 | cryptochrome 1 (photolyase-like) | 1065 | 0.112 | 0.1636 |
| 21 | HSD3B2 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 | 1079 | 0.112 | 0.1701 |
| 22 | ABCB8 | ATP-binding cassette, sub-family B (MDR/TAP), member 8 | 1234 | 0.107 | 0.1698 |
| 23 | GCDH | glutaryl-Coenzyme A dehydrogenase | 1258 | 0.107 | 0.1756 |
| 24 | CASP7 | caspase 7, apoptosis-related cysteine peptidase | 1424 | 0.102 | 0.1744 |
| 25 | MYL10 | myosin, light chain 10, regulatory | 1446 | 0.102 | 0.18 |
| 26 | BCAT2 | branched chain aminotransferase 2, mitochondrial | 1546 | 0.099 | 0.1817 |
| 27 | BZRAP1 | benzodiazapine receptor (peripheral) associated protein 1 | 1591 | 0.098 | 0.186 |
| 28 | MECR | mitochondrial trans-2-enoyl-CoA reductase | 1638 | 0.097 | 0.19 |
| 29 | MTIF3 | Mitochondrial Translational Initiation Factor 3 | 1773 | 0.094 | 0.1898 |
| 30 | BCL2L10 | BCL2-like 10 (apoptosis facilitator) | 1825 | 0.093 | 0.1934 |
| 31 | ACADS | acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain | 1827 | 0.093 | 0.1993 |
| 32 | ECSIT | ECSIT homolog (Drosophila) | 1946 | 0.091 | 0.1996 |
| 33 | MRPL23 | mitochondrial ribosomal protein L23 | 1970 | 0.09 | 0.2043 |
| 34 | MRPS15 | mitochondrial ribosomal protein S15 | 2039 | 0.089 | 0.2068 |
| 35 | MRPS28 | mitochondrial ribosomal protein S28 | 2158 | 0.087 | 0.2068 |
| 36 | TBRG4 | transforming growth factor beta regulator 4 | 2223 | 0.085 | 0.2093 |
| 37 | SLC25A22 | solute carrier family 25 (mitochondrial carrier: glutamate), member 22 | 2236 | 0.085 | 0.2142 |
| 38 | MRPS11 | mitochondrial ribosomal protein S11 | 2257 | 0.085 | 0.2187 |
| 39 | BCKDHA | branched chain keto acid dehydrogenase E1, alpha polypeptide | 2321 | 0.084 | 0.2211 |
| 40 | TRIAP1 | TP53 regulated inhibitor of apoptosis 1 | 2336 | 0.084 | 0.2258 |
| 41 | FDXR | ferredoxin reductase | 2407 | 0.082 | 0.2278 |
| 42 | RHOT2 | ras homolog gene family, member T2 | 2434 | 0.082 | 0.2319 |
| 43 | MRPS24 | mitochondrial ribosomal protein S24 | 2473 | 0.081 | 0.2353 |
| 44 | MRPS35 | mitochondrial ribosomal protein S35 | 2493 | 0.081 | 0.2396 |
| 45 | MTCH1 | mitochondrial carrier homolog 1 (C. elegans) | 2494 | 0.081 | 0.2447 |
| 46 | BCKDK | branched chain ketoacid dehydrogenase kinase | 2503 | 0.081 | 0.2495 |
| 47 | MRPS21 | mitochondrial ribosomal protein S21 | 2584 | 0.079 | 0.2509 |
| 48 | SHMT2 | serine hydroxymethyltransferase 2 (mitochondrial) | 2609 | 0.079 | 0.2548 |
| 49 | PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 2761 | 0.077 | 0.2527 |
| 50 | CPT1A | carnitine palmitoyltransferase 1A (liver) | 2776 | 0.076 | 0.2569 |
| 51 | DMGDH | dimethylglycine dehydrogenase | 2946 | 0.074 | 0.2538 |
| 52 | MSTO1 | misato homolog 1 (Drosophila) | 3029 | 0.073 | 0.2546 |
| 53 | DGUOK | deoxyguanosine kinase | 3045 | 0.073 | 0.2586 |
| 54 | PET112 | glutamyl-TRNA(Gln) amidotransferase, subunit B | 3058 | 0.072 | 0.2626 |
| 55 | AMACR | alpha-methylacyl-CoA racemase | 3069 | 0.072 | 0.2668 |
| 56 | MRPS22 | mitochondrial ribosomal protein S22 | 3103 | 0.072 | 0.2699 |
| 57 | ABCF2 | ATP-binding cassette, sub-family F (GCN20), member 2 | 3118 | 0.072 | 0.2738 |
| 58 | ECI2 | Enoyl-CoA Delta Isomerase 2 | 3129 | 0.072 | 0.2779 |
| 59 | TXNRD2 | thioredoxin reductase 2 | 3191 | 0.071 | 0.2796 |
| 60 | TMEM186 | Transmembrane Protein 186 | 3236 | 0.07 | 0.2821 |
| 61 | PINK1 | PTEN induced putative kinase 1 | 3351 | 0.069 | 0.2812 |
| 62 | ALDH4A1 | aldehyde dehydrogenase 4 family, member A1 | 3430 | 0.068 | 0.2819 |
| 63 | PITRM1 | pitrilysin metallopeptidase 1 | 3500 | 0.067 | 0.283 |
| 64 | PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 3548 | 0.067 | 0.2851 |
| 65 | MIPEP | mitochondrial intermediate peptidase | 3577 | 0.066 | 0.288 |
| 66 | MRPL40 | mitochondrial ribosomal protein L40 | 3589 | 0.066 | 0.2918 |
| 67 | TAMM41 | TAM41 Mitochondrial Translocator Assembly And Maintenance Homolog | 3780 | 0.064 | 0.287 |
| 68 | MSRB2 | methionine sulfoxide reductase B2 | 3929 | 0.063 | 0.2841 |
| 69 | SURF1 | surfeit 1 | 3949 | 0.062 | 0.2872 |
| 70 | ATP5G2 | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C2 (subunit 9) | 3962 | 0.062 | 0.2907 |
| 71 | SPG7 | spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) | 3988 | 0.062 | 0.2935 |
| 72 | BCS1L | BCS1-like (yeast) | 4000 | 0.062 | 0.2969 |
| 73 | ALDH5A1 | aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase) | 4110 | 0.061 | 0.2957 |
| 74 | MARS2 | methionine-tRNA synthetase 2 (mitochondrial) | 4164 | 0.06 | 0.2971 |
| 75 | CLN3 | ceroid-lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease) | 4185 | 0.06 | 0.3 |
| 76 | FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | 4205 | 0.06 | 0.303 |
| 77 | POLG | polymerase (DNA directed), gamma | 4255 | 0.059 | 0.3045 |
| 78 | TUFM | Tu translation elongation factor, mitochondrial | 4299 | 0.059 | 0.3062 |
| 79 | POLG2 | polymerase (DNA directed), gamma 2, accessory subunit | 4333 | 0.059 | 0.3085 |
| 80 | PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 4394 | 0.058 | 0.3094 |
| 81 | COX11 | COX11 homolog, cytochrome c oxidase assembly protein (yeast) | 4427 | 0.058 | 0.3116 |
| 82 | OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | 4436 | 0.058 | 0.3149 |
| 83 | COX15 | COX15 homolog, cytochrome c oxidase assembly protein (yeast) | 4447 | 0.058 | 0.3181 |
| 84 | MCAT | malonyl CoA:ACP acyltransferase (mitochondrial) | 4527 | 0.057 | 0.3181 |
| 85 | DECR1 | 2,4-dienoyl CoA reductase 1, mitochondrial | 4638 | 0.056 | 0.3166 |
| 86 | CASP8 | caspase 8, apoptosis-related cysteine peptidase | 4729 | 0.055 | 0.3159 |
| 87 | TIMM17B | translocase of inner mitochondrial membrane 17 homolog B (yeast) | 4752 | 0.055 | 0.3184 |
| 88 | TIMM50 | translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) | 4791 | 0.055 | 0.3201 |
| 89 | MRPS10 | mitochondrial ribosomal protein S10 | 4848 | 0.054 | 0.321 |
| 90 | AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon) | 4921 | 0.053 | 0.3211 |
| 91 | GBAS | glioblastoma amplified sequence | 4930 | 0.053 | 0.3241 |
| 92 | HSD17B10 | Hydroxysteroid (17-Beta) Dehydrogenase 10 | 4977 | 0.053 | 0.3253 |
| 93 | OXA1L | oxidase (cytochrome c) assembly 1-like | 5075 | 0.052 | 0.3241 |
| 94 | ETFB | electron-transfer-flavoprotein, beta polypeptide | 5085 | 0.052 | 0.327 |
| 95 | MRPL10 | mitochondrial ribosomal protein L10 | 5190 | 0.051 | 0.3254 |
| 96 | PHB2 | prohibitin 2 | 5222 | 0.051 | 0.3272 |
| 97 | COQ4 | coenzyme Q4 homolog (S. cerevisiae) | 5242 | 0.05 | 0.3295 |
| 98 | SDHC | succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa | 5276 | 0.05 | 0.3312 |
| 99 | FDX1 | ferredoxin 1 | 5338 | 0.049 | 0.3315 |
| 100 | THG1L | tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) | 5342 | 0.049 | 0.3345 |
| 101 | AIFM3 | Apoptosis Inducing Factor, Mitochondria Associated 3 | 5344 | 0.049 | 0.3377 |
| 102 | SLC25A15 | solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 | 5345 | 0.049 | 0.3408 |
| 103 | PTGES2 | prostaglandin E synthase 2 | 5367 | 0.049 | 0.343 |