Table 2.
Core enrichment gene list of GSEA for mitochondrial genes in male mice.
| Gene symbol | Gene title | Rank in gene list | Rank metric score | Enrichment score | |
|---|---|---|---|---|---|
| 1 | DBT | dihydrolipoamide branched chain transacylase E2 | 199 | 0.195 | 0.009 |
| 2 | CRY1 | cryptochrome 1 (photolyase-like) | 255 | 0.181 | 0.023 |
| 3 | BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease) | 440 | 0.151 | 0.028 |
| 4 | MAOB | monoamine oxidase B | 458 | 0.149 | 0.041 |
| 5 | HMGCS2 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) | 631 | 0.132 | 0.045 |
| 6 | PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 1006 | 0.106 | 0.037 |
| 7 | ABCB7 | ATP-binding cassette, sub-family B (MDR/TAP), member 7 | 1092 | 0.102 | 0.042 |
| 8 | DUT | dUTP pyrophosphatase | 1286 | 0.095 | 0.042 |
| 9 | METAP1D | Methionyl Aminopeptidase Type 1D (Mitochondrial) | 1303 | 0.094 | 0.050 |
| 10 | GSTZ1 | glutathione transferase zeta 1 (maleylacetoacetate isomerase) | 1346 | 0.092 | 0.057 |
| 11 | UCP3 | uncoupling protein 3 (mitochondrial, proton carrier) | 1489 | 0.088 | 0.058 |
| 12 | NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 1533 | 0.087 | 0.064 |
| 13 | MUT | methylmalonyl Coenzyme A mutase | 1581 | 0.086 | 0.070 |
| 14 | OPA1 | optic atrophy 1 (autosomal dominant) | 1820 | 0.079 | 0.066 |
| 15 | NDUFS5 | NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) | 2107 | 0.073 | 0.059 |
| 16 | ASAH2 | N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 | 2134 | 0.073 | 0.065 |
| 17 | ACOT2 | acyl-CoA thioesterase 2 | 2138 | 0.073 | 0.071 |
| 18 | MTIF2 | mitochondrial translational initiation factor 2 | 2203 | 0.071 | 0.075 |
| 19 | MSRB3 | methionine sulfoxide reductase B3 | 2277 | 0.070 | 0.078 |
| 20 | RAF1 | v-raf-1 murine leukemia viral oncogene homolog 1 | 2334 | 0.069 | 0.082 |
| 21 | GLUD1 | glutamate dehydrogenase 1 | 2407 | 0.068 | 0.084 |
| 22 | ALDH5A1 | aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase) | 2408 | 0.068 | 0.091 |
| 23 | NLRP5 | NLR Family, Pyrin Domain Containing 5 | 2469 | 0.066 | 0.094 |
| 24 | DLD | dihydrolipoamide dehydrogenase | 2485 | 0.066 | 0.099 |
| 25 | PDK1 | pyruvate dehydrogenase kinase, isozyme 1 | 2529 | 0.065 | 0.103 |
| 26 | AASS | aminoadipate-semialdehyde synthase | 2537 | 0.065 | 0.109 |
| 27 | LDHD | lactate dehydrogenase D | 2610 | 0.063 | 0.111 |
| 28 | COX6B2 | cytochrome c oxidase subunit VIb polypeptide 2 (testis) | 2615 | 0.063 | 0.117 |
| 29 | ACAT1 | acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) | 2674 | 0.062 | 0.120 |
| 30 | CLPX | ClpX caseinolytic peptidase X homolog (E. coli) | 2697 | 0.062 | 0.125 |
| 31 | L2HGDH | L-2-hydroxyglutarate dehydrogenase | 2736 | 0.061 | 0.128 |
| 32 | AIFM1 | Apoptosis Inducing Factor, Mitochondria Associated 1 | 2820 | 0.060 | 0.130 |
| 33 | SUCLA2 | succinate-CoA ligase, ADP-forming, beta subunit | 2846 | 0.060 | 0.134 |
| 34 | HCCS | holocytochrome c synthase (cytochrome c heme-lyase) | 2931 | 0.058 | 0.136 |
| 35 | RHOT1 | ras homolog gene family, member T1 | 2974 | 0.058 | 0.139 |
| 36 | BCKDHA | branched chain keto acid dehydrogenase E1, alpha polypeptide | 3019 | 0.057 | 0.142 |
| 37 | ACADSB | acyl-Coenzyme A dehydrogenase, short/branched chain | 3061 | 0.056 | 0.146 |
| 38 | TRNT1 | tRNA nucleotidyl transferase, CCA-adding, 1 | 3237 | 0.053 | 0.142 |
| 39 | ABCE1 | ATP-binding cassette, sub-family E (OABP), member 1 | 3317 | 0.052 | 0.143 |
| 40 | TFB2M | transcription factor B2, mitochondrial | 3417 | 0.051 | 0.143 |
| 41 | GBAS | glioblastoma amplified sequence | 3429 | 0.050 | 0.148 |
| 42 | ETFA | electron-transfer-flavoprotein, alpha polypeptide (glutaric aciduria II) | 3444 | 0.050 | 0.151 |
| 43 | HTRA2 | HtrA serine peptidase 2 | 3461 | 0.050 | 0.155 |
| 44 | HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 3504 | 0.049 | 0.158 |
| 45 | POLG | polymerase (DNA directed), gamma | 3642 | 0.048 | 0.156 |
| 46 | GCDH | glutaryl-Coenzyme A dehydrogenase | 3649 | 0.048 | 0.160 |
| 47 | NIPSNAP1 | nipsnap homolog 1 (C. elegans) | 3769 | 0.046 | 0.159 |
| 48 | TIMMDC1 | Translocase of inner mitochondrial membrane domain-containing protein 1 | 3775 | 0.046 | 0.163 |
| 49 | ACADVL | acyl-Coenzyme A dehydrogenase, very long chain | 3802 | 0.046 | 0.166 |
| 50 | PCCB | propionyl Coenzyme A carboxylase, beta polypeptide | 3920 | 0.045 | 0.164 |
| 51 | MARS2 | methionine-tRNA synthetase 2 (mitochondrial) | 4159 | 0.042 | 0.157 |
| 52 | BID | BH3 interacting domain death agonist | 4214 | 0.042 | 0.158 |
| 53 | COX15 | COX15 homolog, cytochrome c oxidase assembly protein (yeast) | 4259 | 0.041 | 0.160 |
| 54 | HADH | hydroxyacyl-Coenzyme A dehydrogenase | 4307 | 0.041 | 0.162 |
| 55 | DECR1 | 2,4-dienoyl CoA reductase 1, mitochondrial | 4355 | 0.040 | 0.163 |
| 56 | NDUFS1 | NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) | 4356 | 0.040 | 0.167 |
| 57 | OXCT1 | 3-oxoacid CoA transferase 1 | 4385 | 0.040 | 0.169 |
| 58 | BCKDK | branched chain ketoacid dehydrogenase kinase | 4435 | 0.040 | 0.171 |
| 59 | TRIAP1 | TP53 regulated inhibitor of apoptosis 1 | 4508 | 0.039 | 0.171 |
| 60 | PINK1 | PTEN induced putative kinase 1 | 4586 | 0.038 | 0.171 |
| 61 | MRPS28 | mitochondrial ribosomal protein S28 | 4607 | 0.038 | 0.173 |
| 62 | MRPL52 | mitochondrial ribosomal protein L52 | 4667 | 0.037 | 0.174 |
| 63 | PGS1 | phosphatidylglycerophosphate synthase 1 | 4719 | 0.037 | 0.175 |
| 103 | PTGES2 | prostaglandin E synthase 2 | 5367 | 0.049 | 0.343 |