Table 4.
Core enrichment gene list of GSEA for inflammatory response genes in male mice.
| Gene symbol | Gene title | Rank in gene list | Rank metric score | Enrichment score | |
|---|---|---|---|---|---|
| 1 | TIMP1 | TIMP metallopeptidase inhibitor 1 | 3 | 0.804 | 0.061 |
| 2 | CD48 | CD48 molecule | 30 | 0.397 | 0.091 |
| 3 | CD14 | CD14 molecule | 59 | 0.322 | 0.114 |
| 4 | SCN1B | sodium channel, voltage-gated, type I, beta | 76 | 0.303 | 0.136 |
| 5 | CYBB | cytochrome b-245, beta polypeptide (chronic granulomatous disease) | 96 | 0.273 | 0.156 |
| 6 | CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 159 | 0.227 | 0.171 |
| 7 | OSMR | oncostatin M receptor | 163 | 0.223 | 0.188 |
| 8 | C3AR1 | complement component 3a receptor 1 | 215 | 0.200 | 0.201 |
| 9 | CCL7 | chemokine (C-C motif) ligand 7 | 246 | 0.188 | 0.214 |
| 10 | ICAM4 | intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) | 269 | 0.182 | 0.227 |
| 11 | MYC | v-myc myelocytomatosis viral oncogene homolog (avian) | 300 | 0.175 | 0.238 |
| 12 | EMR1 | egf-like module containing, mucin-like, hormone receptor-like 1 | 332 | 0.167 | 0.250 |
| 13 | GCH1 | GTP cyclohydrolase 1 (dopa-responsive dystonia) | 452 | 0.148 | 0.256 |
| 14 | TLR2 | toll-like receptor 2 | 460 | 0.147 | 0.267 |
| 15 | CCL2 | chemokine (C-C motif) ligand 2 | 529 | 0.139 | 0.274 |
| 16 | IL18 | interleukin 18 (interferon-gamma-inducing factor) | 569 | 0.136 | 0.283 |
| 17 | EMP3 | epithelial membrane protein 3 | 627 | 0.132 | 0.290 |
| 18 | PTPRE | protein tyrosine phosphatase, receptor type, E | 654 | 0.130 | 0.299 |
| 19 | EREG | epiregulin | 695 | 0.128 | 0.307 |
| 20 | STAB1 | stabilin 1 | 870 | 0.117 | 0.308 |
| 21 | FZD5 | frizzled homolog 5 (Drosophila) | 891 | 0.117 | 0.316 |
| 22 | RHOG | ras homolog gene family, member G (rho G) | 968 | 0.112 | 0.321 |
| 23 | SERPINE1 | serpin peptidase inhibitor, clade E, member 1 | 1019 | 0.110 | 0.327 |
| 24 | SRI | sorcin | 1079 | 0.108 | 0.332 |
| 25 | SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 1090 | 0.108 | 0.340 |
| 26 | CCL24 | chemokine (C-C motif) ligand 24 | 1246 | 0.102 | 0.341 |
| 27 | LIF | leukemia inhibitory factor (cholinergic differentiation factor) | 1273 | 0.101 | 0.347 |
| 28 | SEMA4D | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D | 1374 | 0.099 | 0.350 |
| 29 | CMKLR1 | chemokine-like receptor 1 | 1397 | 0.098 | 0.357 |
| 30 | P2RX4 | purinergic receptor P2X, ligand-gated ion channel, 4 | 1426 | 0.097 | 0.363 |
| 31 | SLC31A1 | solute carrier family 31 (copper transporters), member 1 | 1443 | 0.097 | 0.370 |
| 32 | IL6 | interleukin 6 (interferon, beta 2) | 1634 | 0.092 | 0.368 |
| 33 | CHST2 | carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 | 1747 | 0.089 | 0.369 |
| 34 | ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 1890 | 0.086 | 0.369 |
| 35 | HBEGF | heparin-binding EGF-like growth factor | 1894 | 0.086 | 0.376 |
| 36 | CX3CL1 | chemokine (C-X3-C motif) ligand 1 | 1920 | 0.086 | 0.381 |