Table 1.
Early-onset versus late-onset group characteristics
| Variable | Early onset, N = 24 | Late onset, N = 28 | P-value |
|---|---|---|---|
| Age at disease onset, y | 54.5 (5.7) | 75.1 (5.6) | <.0001 |
| Age at scan, y | 58.9 (4.9) | 79.4 (5.7) | <.0001 |
| Disease duration | 3.8 (2.9) | 4.1 (2.4) | .7 |
| Education, y | 16.2 (2.2) | 16.0 (2.7) | .8 |
| Sex, M/F | 9/15 | 14/14 | .4 |
| Positive family history, % | 46 | 29 | .2 |
| New patient, % | 50 | 53 | .8 |
| Positive amyloid PET read, % | 80 | 57 | .016 |
| Mean SUVR | 1.42 (0.28) | 1.35 (0.31) | .4 |
| SUVR > 1.17, % | 88 | 61 | .03 |
| Change in diagnosis, % | 17 | 43 | .041 |
| Change in therapy, % | 79 | 59 | .13 |
Abbreviations: PET, positron emission tomography; SUVR, standard uptake volume ratio.
NOTE. Bold text indicates significant P value.