Table 4.
Diagnostic changes in the late-onset AUC-consistent group
| Case | Pre-PET diagnosis | Post-PET diagnosis (if different) | SUVR | Visual read |
|---|---|---|---|---|
| Cases with change in diagnosis | ||||
| LO1 | Atypical MCI | MCI secondary to SNAP/anxiety | 1.061 | neg |
| LO2 | PPA (presumed non-AD)∗ | PPA due to AD | 1.368 | pos |
| LO3 | PPA (presumed non-AD)∗ | PPA due to AD | 1.637 | pos |
| LO4 | AD with CAA | No AD pathology | 1.144 | neg |
| LO5 | Atypical MCI (presumed non-AD)∗ | MCI due to AD | 2.002 | pos |
| LO6 | Mixed dementia | Vascular dementia | 0.874 | neg |
| LO7 | Vascular cognitive impairment (VCI) | Mixed VCI and AD | 1.291 | pos |
| LO8 | Possible AD | Dementia due to drug abuse | 0.916 | neg |
| Cases without change in diagnosis | ||||
| LO9 | Atypical MCI (presumed non-AD - depression)∗ | 1.429 | neg | |
| LO10 | PPA (presumed non-AD)∗ | 1.120 | neg | |
| LO11 | Atypical MCI (presumed SNAP) | 0.998 | neg | |
| LO12 | Atypical AD | 1.431 | pos | |
| LO13 | Atypical AD | 2.050 | pos | |
| LO14 | CAA due to AD | 1.508 | pos | |
| LO15 | DLB | 1.444 | neg | |
Abbreviations: AUC, Appropriate Use Criteria; PET, positron emission tomography; SUVR, standard uptake volume ratio; MCI, mild cognitive impairment; pos, positive; neg, negative; SNAP, suspected non-AD pathophysiology; PPA, primary progressive aphasia; AD, Alzheimer disease; DLB, dementia with Lewy bodies; CAA, cerebral amyloid angiopathy.
∗
Physician-suspected non-AD pathology (with AD in the differential diagnosis).