Table 2.
Cortical thickness of SCD patients with and without clinical progression
| Cortical thickness (mm) | SCD stable (n = 253) | SCD progression to MCI/dementia (n = 49) | SCD progression to MCI (n = 32) | SCD progression to AD (n = 9) | SCD progression to non-AD (n = 8) |
|---|---|---|---|---|---|
| Whole-brain | 2.17 (0.31) | 2.04 (0.37) | 2.15 (0.30)∗ | 1.84 (0.27) | 1.80 (0.48)† |
| AD-signature | 2.39 (0.34) | 2.21 (0.39) | 2.34 (0.35) | 1.96 (0.31) | 2.05 (0.41) |
| Angular gyrus | 2.06 (0.35) | 1.93 (0.37) | 2.04 (0.34) | 2.04 (0.36) | 1.72 (0.37) |
| Precuneus | 1.95 (0.36) | 1.81 (0.39) | 1.98 (0.35)∗ | 1.89 (0.30) | 1.70 (0.39)† |
| Supramarginal | 2.22 (0.32) | 2.10 (0.35) | 2.19 (0.33) | 1.83 (0.33) | 1.93 (0.35) |
| Frontal superior | 2.34 (0.37) | 2.20 (0.40) | 2.30 (0.37) | 1.94 (0.36) | 2.00 (0.40) |
| Parietal superior | 1.80 (0.32) | 1.71 (0.40) | 1.85 (0.30)∗ | 1.71 (0.21) | 1.60 (0.40)† |
| Temporal pole | 3.38 (0.60) | 3.06 (0.65) | 3.24 (0.59) | 2.44 (0.59) | 2.97 (0.65) |
| Temporal inferior | 2.62 (0.32) | 2.44 (0.35) | 2.54 (0.30) | 2.13 (0.36) | 2.29 (0.35) |
| Medial temporal | 2.85 (0.42) | 2.56 (0.47)† | 2.69 (0.44) | 2.16 (0.46) | 2.44 (0.47) |
| Frontal inferior | 2.34 (0.29) | 2.21 (0.32) | 2.28 (0.30) | 1.98 (0.32) | 2.07 (0.32) |
| Hippocampus‡ | 7.18 (0.91) | 6.41 (0.92)† | 6.73 (0.97) | 5.99 (0.92) | 6.84 (0.85) |
Abbreviations: AD, Alzheimer's disease; MCI, mild cognitive impairment; SCD, subjective cognitive decline.
NOTE. Data are presented as the mean (standard deviation). Analyses of variance were used to investigate cortical thickness between groups (SCD stable, MCI, AD, and non-AD) with Bonferroni post hoc tests.
∗
Significantly different between SCD progression to MCI and SCD progression to non-AD.
†
P < .05 significantly different between SCD progression to MCI, AD, or non-AD compared with SCD stable.
‡
In cubic millimeters estimated with FIRST (FMRIB software library v5).