Table 3.
Cortical thickness hazard ratios of SCD patients with progression to MCI, AD, or non-AD dementia or progression to MCI/dementia
| AD-signature components | SCD progression to MCI/dementia (n = 49) | SCD progression to MCI (n = 32) | SCD progression to AD (n = 9) | SCD progression to non-AD (n = 8) |
|---|---|---|---|---|
| Whole-brain thickness | 5 (2–15)∗ | 1 (0–8) | 8 (0–88) | 14 (2–126)∗ |
| AD-signature | 5 (2–17)∗ | 2 (0–9) | 18 (1–284)∗ | 25 (1–433)∗ |
| Angular | 6 (2–20)† | 2 (0–9) | 15 (1–303) | 58 (2–2062)∗ |
| Supramarginal | 4 (1–14)∗ | 1 (0–7) | 6 (1–278)∗ | 29 (1–746)∗ |
| Parietal superior | 7 (1–38)∗ | 1 (0–6) | 126 (1–14,926)∗ | 6225 (6–67,700)∗ |
| Precuneus | 7 (2–25)† | 2 (0–12) | 10 (1–170) | 212 (4–11,636)∗ |
| Frontal inferior | 2 (0–5) | 1 (0–6) | 5 (0–61) | 14 (1–231) |
| Frontal superior | 3 (1–9)∗ | 1 (0–6) | 4 (0–44) | 16 (1–213)∗ |
| Temporal poles | 2 (1–4)∗ | 1 (1–3) | 6 (1–25)∗ | 2 (1–9) |
| Temporal inferior | 4 (1–12) | 2 (0–6) | 12 (1–133)∗ | 14 (1–206) |
| Temporal medial | 5 (2–11)∗ | 3 (1–8) | 14 (2–109)∗ | 11 (1–96)∗ |
| Hippocampus | 2 (1–2)∗ | 2 (1–3)∗ | 2 (1–4)∗ | 1 (0–3) |
Abbreviations: AD, dementia due to Alzheimer's disease; MCI, mild cognitive impairment; non-AD, dementia due to other dementia; SCD, subjective cognitive decline.
NOTE. Data are presented as hazard ratios with accompanying 95% confidence intervals in brackets.
∗
P < .05.
†
P < .01.