Table 1.
Descriptive characteristics and distribution of the genotypes of the MRI sample
| Variables | NC (N = 441) | MCI (N = 764) | DEM (N = 294) | P |
|---|---|---|---|---|
| Age, mean years (SD) | 74.1 (5.7) | 72.6 (7.6) | 74.6 (7.9) | <.001 |
| Sex, N male (%) | 222 (50) | 453 (59) | 165 (56) | .01 |
| Education, mean years (SD) | 16.4 (2.6) | 16.0 (2.8) | 15.2 (3.0) | <.001 |
| MMSE, mean (SD) | 29.1 (1.1) | 27.6 (1.8) | 23.3 (2.1) | <.001 |
| APOE ε4, % 0/1/2 | 71/27/2 | 49/40/11 | 34/47/19 | <.001 |
| ABCA7 rs3752246, % 0/1/2 | 69/29/2 | 68/28/4 | 67/30/3 | .58 |
| CELF1 rs10838725, % 0/1/2 | 46/45/9 | 44/46/10 | 45/48/7 | .45 |
| EPHA1 rs11771145, % 0/1/2 | 44/44/12 | 43/45/12 | 45/42/13 | .95 |
| FERMT2 rs17125944, % 0/1 | 85/15 | 84/16 | 78/22 | .02 |
| INPP5D rs35349669, % 0/1/2 | 30/48/22 | 30/46/24 | 26/51/23 | .52 |
| SLC24A4/RIN3 rs10498633, % 0/1/2 | 60/35/5 | 61/34/5 | 60/35/5 | .99 |
| ZCWPW1 rs1476679, % 0/1/2 | 50/41/9 | 51/41/8 | 60/33/7 | .08 |
Abbreviations: MRI, magnetic resonance imaging; NC, normal control; MCI, mild cognitive impairment; DEM, dementia; SD, standard deviation.
NOTE. Bold text indicates a significant P value (P <0.05).