Table 2.
Descriptive characteristics and distribution of the genotypes of the FDG PET sample
| Variables | NC (N = 381) | MCI (N = 634) | DEM (N = 243) | P |
|---|---|---|---|---|
| Age, mean years (SD) | 74.3 (6.2) | 72.6 (7.6) | 75.0 (7.7) | <.001 |
| Sex, N male (%) | 190 (50) | 380 (60) | 148 (61) | .003 |
| Education, mean years (SD) | 16.4 (2.7) | 16.1 (2.7) | 15.4 (2.9) | <.001 |
| MMSE, mean (SD) | 29.0 (1.2) | 27.8 (1.8) | 23.1 (2.8) | <.001 |
| APOE ε4, % 0/1/2 | 73/25/2 | 51/38/11 | 33/50/17 | <.001 |
| CD2AP rs9349407, % 0/1/2 | 49/44/7 | 53/40/7 | 49/40/11 | .22 |
| CELF1 rs10838725, % 0/1/2 | 48/42/10 | 44/46/10 | 43/50/4 | .27 |
| CLU rs11136000, % 0/1/2 | 36/50/14 | 37/50/13 | 43/42/15 | .28 |
| CLU rs9331949, % 0/1 | 95/5 | 97/3 | 95/5 | .31 |
| CR1 rs12034383, % 0/1/2 | 14/49/37 | 15/48/37 | 21/46/33 | .19 |
| DSG2 rs8093731, % 0/1 | 98/2 | 98/2 | 97/3 | .84 |
| EPHA1 rs11771145, % 0/1/2 | 44/44/12 | 45/42/13 | 43/44/13 | .94 |
| EPHA1 rs11767557, % 0/1/2 | 66/30/4 | 70/27/3 | 63/34/3 | .29 |
| MS4A6A rs610932, % 0/1/2 | 31/48/21 | 37/47/16 | 38/45/17 | .25 |
| NME8 rs2718058, % 0/1/2 | 39/47/14 | 40/45/15 | 38/49/13 | .88 |
| PTK2B rs28834970, % 0/1/2 | 42/42/16 | 42/42/16 | 39/49/12 | .39 |
| SLC24A4/RIN3 rs10498633, % 0/1/2 | 61/34/5 | 62/34/4 | 58/37/5 | .87 |
| SORL1 rs11218343, % 0/1 | 91/9 | 92/8 | 93/7 | .55 |
Abbreviations: FDG PET, F18-fluorodeoxyglucose positron emission tomography; NC, normal control; MCI, mild cognitive impairment; DEM, dementia; SD, standard deviation; MMSE, Mini–Mental State Examination.
NOTE. Bold text indicates a significant P value (P <0.05).