Table 3.

Family-wise error (FWE) and false discovery rate (FDR)-corrected cluster analyses and within-cluster peak effects for the genetic variants identified in the exploratory MRI analyses

DX group	Gene variant	Cluster-level				Peak level		Talairach coordinates	Brain region (Brodmann area [BA])
		pFWE-corr	qFDR-corr	kE	puncorr	T	puncorr
DEM	ABCA7 rs3752246	<.0001	<0.0001	924757	<.0001	9.72	<.0001	−11 −23 63	L medial frontal gyrus (BA6)
	EPHA1 rs11771145	.04	0.051	13,081	.001	3.86	<.0001	−52 −28 61	L postcentral gyrus (BA2)
		.007	0.017	1889	<.0001	4.01	<.0001	52 −30 59	R postcentral gyrus (BA2)
	SLC24A4/RIN3 rs10498633	.007	0.012	18,621	<.0001	3.78	<.0001	−14 1 46	L cingulate gyrus (BA24)

Abbreviations: MRI, magnetic resonance imaging; pFWE-corr, family-wise error-corrected P-value; qFDR-corr, false discovery rate–corrected q-value; kE, cluster size; p_uncorr, uncorrected P-value; T, T statistic; DEM, dementia.

NOTE. Bold text indicates a significant P value (P <0.05).