Table 3.
DX group | Gene variant | Cluster-level |
Peak level |
Talairach coordinates | Brain region (Brodmann area [BA]) | ||||
---|---|---|---|---|---|---|---|---|---|
pFWE-corr | qFDR-corr | kE | puncorr | T | puncorr | ||||
DEM | ABCA7 rs3752246 | <.0001 | <0.0001 | 924757 | <.0001 | 9.72 | <.0001 | −11 −23 63 | L medial frontal gyrus (BA6) |
EPHA1 rs11771145 | .04 | 0.051 | 13,081 | .001 | 3.86 | <.0001 | −52 −28 61 | L postcentral gyrus (BA2) | |
.007 | 0.017 | 1889 | <.0001 | 4.01 | <.0001 | 52 −30 59 | R postcentral gyrus (BA2) | ||
SLC24A4/RIN3 rs10498633 | .007 | 0.012 | 18,621 | <.0001 | 3.78 | <.0001 | −14 1 46 | L cingulate gyrus (BA24) |
Abbreviations: MRI, magnetic resonance imaging; pFWE-corr, family-wise error-corrected P-value; qFDR-corr, false discovery rate–corrected q-value; kE, cluster size; puncorr, uncorrected P-value; T, T statistic; DEM, dementia.
NOTE. Bold text indicates a significant P value (P <0.05).