Table 4.

Family-wise error (FWE) and false discovery rate (FDR)-corrected cluster-level analyses and within-cluster peak effects for genetic variants identified in the exploratory FDG PET analyses

Diagnostic group	Gene variant	Cluster				Peak effect		Talairach coordinates	Brain region (Brodmann area [BA])
		pFWE-corr	qFDR-corr	kE	puncorr	T	puncorr
Pooled sample	CLU rs1113600	<.0001	<0.0001	5979	<.0001	4.02	<.0001	−48 −4 −32	L inferior temporal gyrus (BA20)
		.027	0.025	1493	<.0001	4.01	<.0001	64 −18 8	R transverse temporal gyrus (BA42)
	EPHA1 rs11771145	.049	0.102	1314	.0001	3.8	<.0001	−14 −50 60	L superior parietal lobule (BA7)
	MS4A6A rs610932	.001	0.001	2723	<.0001	4.28	<.0001	40 −14 42	R precentral gyrus (BA4)
	PTK2B rs28834970	.002	0.003	2426	<.0001	3.96	<.0001	−2 −74 −2	L lingual gyrus (BA18)
NC	CELF1 rs10838725	.004	0.004	1960	<.0001	4.19	<.0001	20 −66 44	R precuneus (BA7)
		<.0001	<0.0001	2718	<.0001	3.88	<.0001	0 52 −12	L medial frontal gyrus (BA10)
		.017	0.012	1514	<.0001	3.5	<.0001	32 −38 −4	R subgyral, hippocampus
	CR1 rs12034383	<.0001	<0.0001	37,014	<.0001	4.98	<.0001	18 −36 30	R cingulate gyrus (BA31)
	DSG2 rs8093731	.017	0.008	1515	<.0001	4.15	<.0001	6 −4 50	R medial frontal gyrus (BA6)
	PTK2B rs28834970	<.0001	<0.0001	6279	<.0001	4.24	<.0001	44 −22 6	L superior temproral gyrus (BA13)
		<.0001	<0.0001	6722	<.0001	3.98	<.0001	−42 −36 12	L superior temproral gyrus (BA41)
	SLC24A4/RIN3 rs10498633	<.0001	<0.0001	20,054	<.0001	4.38	<.0001	22 −4 −30	R parahippocampal gyrus (BA36)
		.007	0.004	1767	<.001	3.71	<.0001	−22 −8 −30	L parahippocampal gyrus (BA36)
DEM	NME8 rs2718058	<.001	<0.001	3551	<.001	4.52	<.0001	−14 −88 30	L cuneus (BA19)

Abbreviations: FDG PET, F18-fluorodeoxyglucose positron emission tomography; pFWE-corr, family-wise error-corrected P-value; qFDR-corr, false discovery rate–corrected q-value; kE, cluster size; p_uncorr, uncorrected P-value; T, T statistic; NC, normal control; DEM, dementia.

NOTE. Bold text indicates a significant P value (P <0.05).