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. 2016 Dec 19;107(12):1867–1876. doi: 10.1111/cas.13092

Figure 5.

Figure 5

INC280 abrogates the growth of Yamato‐SS xenograft tumors by inactivating c‐MET signaling. (a) Effects of INC280 on Yamato‐SS xenograft tumor growth. Mice bearing Yamato‐SS (n = 6/group each) xenograft tumors were treated with 3 mg/kg INC280, 10 mg/kg INC280 or vehicle control. Points, mean; bars, SD. *P < 0.05, compared with control treatment. (b) Immunohistochemical staining of p‐MET, PCNA and cleaved caspase‐3 in Yamato‐SS xenograft tumors in the three groups. Scale bars: 100 μm. (c) PCNA‐positive rates of Yamato‐SS xenograft tumors in the three groups. Columns, mean; bars, SD. *P < 0.05, compared with control treatment. (d) Cleaved caspase‐3‐positive rates of Yamato‐SS xenograft tumors in the three groups. Columns, mean; bars, SD. *P < 0.05, compared with control treatment.