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. 2016 Dec 29;11(12):e0167272. doi: 10.1371/journal.pone.0167272

Fig 1. The combination of AZD-2281 and IR did not reduce tumor growth.

Fig 1

(A) Tumor bearing animals (n = 10 per group) were treated with vehicle, 7 days of daily 150mg/kg Olaparib po, a single dose 12Gy or the combination of Olaparib and IR. For the combination, animals were treated daily with 150mg/kg Olaparib po for 7 days followed by two days of wash-out and a single dose of 12Gy of IR. Four tumors per group were harvested for histological analysis on day 10. (B) Tumor volume was evaluated 3 times a week. (C) Data from (B) quantitated as fold change in tumor volume (TV) and tumor growth delay (TGD). Error bars represent SD. (D) Survival in response to treatment was measured until mice either reached the humane tumor endpoint or their natural life span in the case of no recurrence of the tumor after treatment.