Table 2. Regression model coefficient point estimates (95% CI) for models of VA outcomes as a function of ALS disease variables with control subjects assumed to have no limitations.

Visual acuity outcome	Functional impairment (48-ALSFRS-R)	Functional impairment (MMT)	Disease duration (years)
100% HCVA	-0.10 (-0.32, 0.11)	-0.01 (-0.09, 0.10)	0.24 (-0.74, 1.22)
	p = 0.35	p = 0.93	p = 0.63
2.5% LCVA	-0.15 (-0.50, 0.21)	-0.04 (-0.21, 0.17)	-0.71 (-2.95, 1.53)
	p = 0.41	p = 0.68	p = 0.53
1.25% LCVA	-0.30 (-0.61, 0.02)	-0.04 (-0.19, 0.12)	-1.92 (-3.42, -0.42)
	p = 0.07	p = 0.64	p = 0.01

HCVA: high contrast visual acuity, LCVA: low contrast visual acuity, ALSFRS-R: amyotrophic lateral sclerosis functional rating score with respiration, MMT: manual motor testing,

Coefficients are from generalized estimating models of monocular VA accounting for age and within subject correlation