Fig 5. Non-survivors produce less EBV-specific IFN-γ, and from difference T cell subsets.

Among IFN-γ producers, there was no difference in the magnitude of CD4⁺ T cell IFN-γ production in response to EBNA-1 or PfSEA-1 stimulation between eBL survivor and non survivors (A), non-survivors produced less CD8⁺ T cell IFN-γ from EBNA-1 stimulated cells (B). Among EBNA-1-specific CD8⁺ T cell IFN-γ producers, survivors produced more CD8⁺ T cell IFN-γ from the CD45RA^-CCR7^- effector memory (T_EM) cell subset than non-survivors (C). Among PfSEA-1-specific CD8⁺ T cell IFN-γ producers, there was no difference between survivors and non-survivors in the cell type that produced IFN-γ (D). Among IFN-γ T cell responders in both survivors and non-survivors, CD25⁺Foxp3⁺ Treg frequency negatively correlated with CD8⁺ T cell EBNA-1 IFN-γ production (E).