Figure 2. Native interactions are confined by TAD boundaries and describe prelooping.

i4C‐seq was performed in HUVECs using NlaIII and the TSSs of BMP4, CDKN3, CNIH, and SAMD4A as viewpoints (triangles). Interactions are shown aligned to TAD boundaries (gray rectangles; from Dixon et al, 2012) and HUVEC ENCODE ChIP‐seq data (below). Prelooping of the SAMD4A and BMP4 TNF‐responsive TSSs to enhancers is indicated (orange lines).