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. 2016 Dec 9;12(12):891. doi: 10.15252/msb.20167311

Figure 4. 3D organization of a 2.8‐Mbp human locus analyzed by iT2C/conventional T2C.

Figure 4

  1. Interaction maps from conventional T2C (left) and iT2C (middle, right) in the 2.8 Mbp around SAMD4A on chromosome 14. Magnifications show interactions at increasingly higher resolution. Bottom: HUVEC ENCODE ChIP‐seq data are aligned to interactions mapped at 1.5‐kbp resolution in the 250 kbp around SAMD4A.
  2. PE‐SCAN graphs (see de Wit et al, 2013) show the enrichment of iT2C interactions (± 5 kbp) for CTCF (gray), H3K27ac (pink), and H3K27me3 (blue), while H3K9me3 (brown) that is absent from this region serves as a control.