Figure 1. Methods to study native chromatin organization.

(A) Conventional chromatin conformation capture. In conventional methods for studying chromatin organization, chromatin is crosslinked and processed in non‐physiological buffers. (B) Intrinsic chromatin conformation capture. i3C and related methods do not use crosslinking and are performed in a physiological buffer including washes to reduce bystander interactions. (C) TALE‐ID. Specific loci can be targeted using a TALE‐Dam fusion protein, which methylates any site (red) interacting with the targeted anchor (blue).