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Schema showing HNSCC-associated changes in metabolic flux. (A) Metabolic processes in healthy, non-cancer cells, with energy flow driven primarily by glucose metabolism (glycolysis, TCA cycle). In cancer cells (B), levels of acyl carnitines and polyamines are elevated, suggesting amino acid and fatty acid metabolism to be major sources of energy production. Cancer cells also produce 2HG, indicating specific variations in the TCA cycle.
