Table 3.
Overview of the number of annotated antimicrobials and combinations
| Microorganism | AMP combination with |
Mode of growth |
Experimental test |
Combination type |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| AMP | Anti(B/F) | P | B | CKB and/or FIC/FBC | T-K | S | Ad | I | A | |
| P. aeruginosa | 59 (8.97%) | 489 (74.3%) | 628 (95.4%) | 18 (2.73%) | 399 (60.7%) | 85 (12.9%) | 317 (48.2%) | 118 (19.6%) | 164 (24.9%) | 48 (7.29%) |
| S. aureus | 47 (10.2%) | 280 (60.6%) | 398 (86.2%) | 40 (8.66%) | 259 (56.1%) | 44 (9.52%) | 238 (51.5%) | 127 (27.5%) | 62 (13.4%) | 35 (7.58%) |
| E. coli | 53 (18.7%) | 105 (37.1%) | 268 (94.7%) | 6 (2.12%) | 152 (53.7%) | 18 (6.36%) | 102 (36.0%) | 68 (24.0%) | 71 (25.1%) | 42 (14.9%) |
| L. monocytogenes | 10 (17.9%) | 0 | 47 (83.9%) | 0 | 12 (21.4%) | 0 | 38 (67.9%) | 5 (8.93%) | 13 (23.2%) | 0 |
| C. albicans | 1 (1.03%) | 51 (52.6%) | 96 (99.0%) | 0 | 55 (56.7%) | 3 (3.09%) | 54 (55.7%) | 10 (10.3%) | 11 (11.3%) | 22 (22.7%) |
Legend: Anti(B/F), antibiotic and antifungal; P, planktonic; B, biofilm; CKB, checkerboard; T-K, time-kill; S, synergic; Ad, additive; I, indifferent; A, antagonic.
Note: Synergic/additive plus additive/indifferent, and indifferent/antagonic combinations are included in the Ad and I categories, respectively. The percentages are relative to the total number of combinations for each microorganism.