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. 2016 Dec 20;5:e21616. doi: 10.7554/eLife.21616

Figure 6. The abnormal autonomous activity of STN neurons in BACHD mice is rescued by inhibition of KATP channels with gliclazide.

Figure 6.

(A) Examples of loose-seal cell-attached recordings of a STN neuron from a 6-month-old BACHD mouse before (upper) and after (lower) inhibition of KATP channels with 10 µM gliclazide. (B) Population data (5–7-month-old). In BACHD STN neurons inhibition of KATP channels with gliclazide increased the frequency and regularity of firing. *p < 0.05. Data for panel B provided in Figure 6—source data 1.

DOI: http://dx.doi.org/10.7554/eLife.21616.016

Figure 6—source data 1. Autonomous firing frequency and CV for WT and BACHD STN neurons under control conditions and following gliclazide application in Figure 6B.
DOI: http://dx.doi.org/10.7554/eLife.21616.017
elife-21616-fig6-data1.xlsx (34.4KB, xlsx)
DOI: 10.7554/eLife.21616.017