Figure 8. Break down of H₂O₂ by catalase rescues autonomous firing in BACHD STN neurons.

(A) Example showing the instantaneous firing rate of a BACHD STN neuron in control conditions, during the application of catalase (250 U/ml), and during co-application of catalase and glibenclamide (100 nM). (B1) Example of BACHD STN neuron firing in control conditions (marked 1 in A). (B2) Example of elevated firing during break down of H₂O₂ by catalase (marked 2 in A). (B3) Example showing no further elevation of firing rate during additional inhibition of K_ATP channels with glibenclamide (marked 3 in A). (C) Population data from 4–6-month old BACHD mice showing an increase in the frequency and regularity of firing following break down of H₂O₂, with no further changes upon K_ATP channel inhibition. (D) Population data showing an increase in the frequency and regularity of firing following K_ATP channel inhibition with no further change in firing rate and a slight increase in firing regularity upon H₂O₂ break down. *p < 0.05. ns, not significant. Data for panels C–D provided in Figure 8—source data 1.

DOI: http://dx.doi.org/10.7554/eLife.21616.021