Table 2.
miRNA-candidate studies that showed an alteration of miRNA-34a expression after ionizing radiation.
| Species | Cell type | Cell lines | Irradiation dose (Gy) |
Collection time after radiation (h) |
Expression | Ref. |
|---|---|---|---|---|---|---|
| Human | Breast | HMEC | 0.1 & 2.5 | 6, 12, 24, 48 & 96 |
↑ at 96h after 0.1 & 2.5Gy | (Wang et al., 2013) |
| Human | Lymphoblast | TK6 NH32 WTK1 |
0.73, 1.5, 3 & 6 | 6, 12, 24, 48 & 72 |
↑ at 48h after all doses for TK6 ↑ at 48h after 3 & 6Gy for NH32 & WTK1 ↑ at 24 & 48h after 0.73Gy for TK6 |
(Chen et al., 2012) |
| Human | Nasopharynx | CNE1 CNE2 |
5×2 & 4×2.33 5×2 & 4×2.43 |
- | ↑ for all cell lines & all doses | (Long et al., 2014) |
| Human | Cervix Breast |
HeLa MCF-7 |
2 & 5 Gy | 24 | ↑ in HeLa after 2 & 5Gy | (Mert et al., 2012) |
| Human | Breast | MCF-7 MCF- 10A TD-47 |
0.003, 0.012, 0.048 & 5 |
4 & 24 | ↑ in MCF-10A at 4h after 4 all doses & at 24h after 0.012Gy ↑ in MCF-7 at 24h after 0.003Gy |
(Stankevicins et al., 2013) |
| Human | Lung | A549 | 4 | 6, 12, 18, 24 & 36 |
↑ at 18, 24 & 48h | (Salzman et al., 2016) |
| Human | Serum | In vivo | RT: 50Gy to the tumor (25×2Gy) |
24 after the end of RT |
↑ | (Halimi et al., 2016) |
| Mouse | Spleen | In vivo | 6 | 4 & 8 | ↑ | (He et al., 2007b) |
| Mouse | Spleen Thymus Liver Serum |
BALB/c C57BL/6 |
2, 7 & 12 (WBI) | 4, 8, 24 & 48 | ↑ in all 3 tissue at 8h after 7Gy ↑ in spleen & serum at 8h after 2, 7 & 12Gy ↑ in serum at 8h after 2, 7 & 12Gy ↑ in serum at 4, 8, 24 & 48h after 7Gy |
(Liu et al., 2011) |
| Human | Colon | HCT116 | 2, 4 & 8 | 4, 8, 24 & 48 | ↑ at 8h after 2, 4 & 8Gy ↑ at 4, 8 & 24h after 4Gy |
(Liu et al., 2011) |
| C. elegans | Wild-type N2 cep-1/p53 mutants |
In vivo | 200 (WBI) | 3, 6 & 9 | ↑ at 3h | (Kato et al., 2009) |
RT: Radiation treatment; WBI: Whole-Body Irradiation