Table 2.
Most significant GO terms, biological functions, and disorders associated with 161 differentially expressed genes in autistic patient iPSC-derived neurons a
| Gene Ontology Term & Category | Enrichment p value |
|---|---|
| GO term (GO ID) | |
| Biological process | |
|
| |
| Nervous system development (GO: 0007399) | 7·0E-10 |
|
| |
| Transmission of nerve impulse (GO: 00192260) | 4·2E-07 |
| Cellular component | |
|
| |
| Synapse (GO: 0045202) | 9·5E-06 |
|
| |
| Ion channel complex (GO: 0034702) | 6·0E-05 |
|
| |
| Extracellular matrix (GO: 0031012) | 1·6E-04 |
|
| |
| Integral to plasma membrane (GO: 0005887) | 3·7E-04 |
|
| |
| Neuron projection (GO: 0043005) | 2·4E-03 |
|
| |
| Molecular function | |
|
| |
| Neurotransmitter receptor activity (GO: 0030594) | 1·6E-05 |
|
| |
| Neurotransmitter binding (GO: 0030594) | 2·6E-05 |
|
| |
| Gated channel activity (GO: 0022836) | 6·4E-05 |
|
| |
| Ion channel activity (GO: 0005216) | 4·3E-04 |
|
| |
| KEGG pathway (pathway ID) | |
|
| |
| Nicotine addiction (hsa05033) | 8·4E-07 |
|
| |
| GABAergic synapse (hsa04727) | 8·3E-06 |
|
| |
| Morphine addiction (hsa05032) | 8·9E-06 |
|
| |
| Retrograde endocannabinoid signaling (hsa04723) | 2·0E-05 |
|
| |
| Neuroactive ligand-receptor interaction (hsa04080) | 6·6E-05 |
|
| |
| PI3K-Akt signaling pathway (hsa04151) | 1·9E-03 |
|
| |
| ECM-receptor interaction (hsa04512) | 5·8E-03 |
|
| |
| Panther pathway (pathway ID) | |
|
| |
| Cadherin signaling pathway (P00012) | 5·9E-02 |
|
| |
| Metabotropic glutamate receptor group II pathway (P00040) | 8·7E-02 |
|
| |
| Ionotropic glutamate receptor pathway (P00037) | 9·6E-02 |
|
| |
| Associated disease (Autworks: Gene-disease association analysis) | |
|
| |
| Schizophrenia, Childhood | 2·0E-03 |
|
| |
| Waardenburg’s Syndrome | 4·0E-03 |
|
| |
| Neurotic Disorders | 6·0E-03 |
|
| |
| Epilepsy, Generalized | 6·0E-03 |
|
| |
| Multiple Sclerosis, Chronic Progressive | 4·2E-02 |
|
| |
| Autistic Disorder | 4·9E-02 |
a
Source of analysis:
Partek Genomics Suite; DAVID Bio-informational database; Ingenuity Pathway Analysis database; Autworks Gene-disease association analysis.
Abbreviations: Akt = A serine/threonine-specific protein kinase, also known as Protein kinase B; ECM = Extracellular matrix; PI3K = Phosphatidylinositol-4,5-bisphosphate 3-kinase, now known as PIK3CA.