Table 1.
Characteristics of the prostate cancer patient populations
| FH patients (Discovery cohort) | EV patients (Validation dataset) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Non-recurrence (n = 303) | Metastatic-lethal PCa (n = 24) | Non-recurrence (n = 41) | Metastatic-lethal PCa (n = 24) | |||||||||||
| Characteristic | No. | Mean (SD) | No. | % | Mean (SD) | P-valuea | No. | % | Mean (SD) | No. | % | Mean (SD) | P-valuea | |
| Age at diagnosis (years) | 58.2 (7.1) | 58.6 (7.3) | 0.76 | 60.2 (6.0) | 60.3 (5.7) | 0.97 | ||||||||
| Gleason sum | <0.01 | <0.01 | ||||||||||||
| ≤ 6 | 173 | 57.1 | 5 | 20.8 | 13 | 31.7 | 2 | 8.3 | ||||||
| 7 (3+4) | 101 | 33.3 | 8 | 33.3 | 24 | 58.5 | 5 | 20.8 | ||||||
| 7 (4+3) | 16 | 5.3 | 5 | 20.8 | 1 | 2.4 | 5 | 20.8 | ||||||
| 8–10 | 13 | 4.3 | 6 | 25.0 | 3 | 7.3 | 12 | 50.0 | ||||||
| Pathological stageb | <0.01 | <0.01 | ||||||||||||
| Local | 235 | 77.6 | 11 | 45.8 | 22 | 53.7 | 0 | 0.0 | ||||||
| Regional | 68 | 22.4 | 13 | 54.2 | 19 | 46.3 | 24 | 100.0 | ||||||
| PSA (ng/mL) at diagnosis | <0.01 | <0.01 | ||||||||||||
| < 4.0 | 54 | 17.8 | 2 | 8.3 | 10 | 24.4 | 3 | 12.5 | ||||||
| 4.0–4.9 | 189 | 62.4 | 7 | 29.2 | 27 | 65.9 | 14 | 58.3 | ||||||
| 10.0–19.9 | 28 | 9.2 | 5 | 20.8 | 2 | 4.9 | 5 | 20.8 | ||||||
| ≥ 20 | 14 | 4.6 | 7 | 29.2 | 1 | 2.4 | 2 | 8.3 | ||||||
Note: PCa = prostate cancer; FH = Fred Hutchinson; EV = Eastern Virginia
a
A t-test (age) or chi-square test was used (all categorical variables).
b
Local stage = pT2, N0/NX, M0; Regional stage = pT3/T4 and/or N1, M0.