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. Author manuscript; available in PMC: 2017 Mar 6.
Published in final edited form as: Mucosal Immunol. 2016 Jun 29;10(2):434–445. doi: 10.1038/mi.2016.55

Figure 2. Adoptive transfer of WT Ly6Chi monocytes into Nlrp6−/− mice significantly reduces tumor growth in AOM/DSS model of colitis-associated tumorigenesis.

Figure 2

(a) Age and sex-matched Nlrp6−/− and WT mice were treated with AOM followed by three 5-day cycles of 2% DSS. Sorted Ly6Chi monocytes were injected i.v. 3.5 days after the start of each DSS cycle. Three weeks after the last cycle of DSS mice were sacrificed and tumors grossly counted with a stereomicroscope. Number (b) and size (c) of tumors are shown. (d) Percent weight change during AOM/DSS treatment. Data are representative of three independent experiments, n=15, n=10, n=19, n=22 for WT, WT + WT Ly6Chi monocytes, Nlrp6−/− and Nlrp6−/− + WT Ly6Chi monocytes groups respectively. *, ** - p<0.05, p<0.001, respectively, as compared to WT (b) or Nlrp6−/− mice (d).