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. 2017 Jan 3;127(1):65–73. doi: 10.1172/JCI88882

Figure 2. A developmental framework for the initiation of metainflammation.

Figure 2

Throughout the life-course there are multiple initiating events that can lead to the expansion of adipose tissue and systemic chronic inflammation. These include programmed inheritance (orange), environmental factors (green), intrinsic growth rates of the child (red), and adipose tissue metabolic impairments (purple).