Table 1.
Characteristics of Patients by BMI Group
| Whole Cohort n = 331 |
Underweight n = 40 |
Normal Weight n = 165 |
Overweight n = 35 |
Obese n = 91 |
p-value | |
|---|---|---|---|---|---|---|
| Mean Age, years (SD) | 9.6 (5.1) | 7.1 (4.3) | 10.3 (5.2) | 9.8 (5) | 9.3 (5) | 0.003b |
| Male, n (%) | 182 (55) | 23 (58) | 89 (54) | 17 (49) | 53 (58) | 0.77c |
| Race/Ethnicity, n (%) | 0.08c | |||||
| Caucasian | 185 (56) | 20 (50) | 88 (53) | 21 (60) | 56 (61.5) | |
| African American | 60 (18) | 5 (12.5) | 22 (20) | 9 (26) | 13 (14) | |
| Asian/Pacific Islander | 14 (4) | 5 (12.5) | 8 (5) | 0 (0) | 1 (1) | |
| Hispanic/Latino | 48 (14.5) | 5 (12.5) | 22 (13) | 4 (11) | 17 (19) | |
| Other | 24 (7) | 5 (12.5) | 14 (8.5) | 1 (3) | 4 (4) | |
| Any Past Medical History, n (%) | 194 (59) | 27 (67.5) | 95 (58) | 14 (40) | 58 (64) | 0.085c |
| Prior Pulmonary Disease, n (%)a | 34 (10) | 6 (15) | 8 (5) | 3 (9) | 17 (19) | 0.004c |
| Immunocompromised, n (%)a | 69 (21) | 5 (12.5) | 39 (24) | 4 (11) | 21 (23) | 0.2c |
| Indirect Lung Injury, n (%) | 81 (24) | 4 (10.5) | 52 (34) | 7 (20) | 18 (21) | 0.03c |
| ARDS Etiology, n (%) | 0.013c | |||||
| Pneumonia | 149 (45) | 24 (60) | 68 (41) | 14 (40) | 43 (47) | |
| Sepsis | 43 (13) | 0 (0) | 30 (18) | 1 (3) | 12 (13) | |
| Aspiration | 38 (11.5) | 5 (12.5) | 13 (8) | 5 (14) | 15 (16.5) | |
| Trauma | 21 (6) | 1 (2.5) | 12 (7) | 6 (17) | 2 (2) | |
| Near Drowning | 16 (5) | 1 (2.5) | 6 (4) | 4 (11) | 5 (5.5) | |
| TRALI | 13 (4) | 3 (7.5) | 8 (5) | 0 (0) | 2 (2) | |
| Pulmonary Hemorrhage | 13 (4) | 2 (5) | 6 (4) | 2 (6) | 3 (3) | |
| Other | 38 (11.5) | 4 (10) | 22 (13) | 3 (9) | 9 (10) | |
| Median PF Ratio at Diagnosis (IQR) | 123.6 (84, 167) | 118.5 (77, 165) | 116 (61, 165) | 152 (115, 202) | 126 (79, 160) | 0.06b |
| Median PRISM-III Score (IQR) | 11 (6, 16) | 12 (6, 17) | 10 (5, 16) | 10 (5, 16) | 11 (6, 16) | 0.53b |
| Study, n (%) | 0.93c | |||||
| 1 | 88 (27) | 10 (1) | 49 (56) | 10 (11) | 19 (22) | |
| 2 | 40 (12) | 5 (12.5) | 19 (47.5) | 4 (10) | 12 (30) | |
| 3 | 55 (17) | 6 (11) | 24 (44) | 8 (15) | 17 (31) | |
| 4 | 52 (16) | 8 (25) | 25 (48) | 6 (11.5) | 13 (25) | |
| 5 | 96 (29) | 11 (11.5) | 48 (50) | 7 (7) | 30 (30) | |
| Died, n (%) | ||||||
| Indirect Lung Injury | 21 (26) | 2 (50) | 16 (31) | 1 (14) | 2 (11) | 0.2c |
| Direct lung Injury | 38 (16) | 6 (18) | 17 (17) | 3 (11) | 12 (18) | 0.9c |
| Total | 65 (20) | 8 (20) | 38 (23) | 4 (11) | 15 (16) | 0.4c |
a
May be less than expected as entity was an exclusion criteria for one or more studies combined to form this cohort
b
p values obtained using Kruskal-Wallis test or ANOVA with Bonferroni
c
p values obtained using chi-square comparisons
d
p values obtained using Student’s t-test
Abbreviations: SD=standard deviation; IQR=interquartile range