Figure 4. Top IPA generated networks up‐regulated in 8‐ vs. 14‐week old wheel running rats.

Top associated networks as defined by IPA for NAc mRNAs differently expressed in 8‐ and 14‐week‐old wheel running rats included (A) ‘nervous system and function, organ morphology, and organismal development’ (Focus molecules: 24/35; Score: 35) and (B) ‘cellular assembly and organization, nervous system development and function, and tissue morphology’ (Focus molecules: 23/35; Score: 35). Nodes represent genes/molecules. Shading is proportional to fold change size (red, up‐regulated; green, down‐regulated). Direct and indirect relationships are denoted with solid and dashed lines, respectively. White nodes denote network members that were not altered in the network. Lines ending in an arrow or blunt end indicate the known direction of molecular activation or inhibition, respectively.