Figure 7. Dendritic spine density is increased in 8‐ vs. 14‐week old wheel running and sedentary rats.

A, Darrp‐32 protein was not different between any of the four experimental groups assessed. B, analysis of dendritic spine density showed that wheel running increased spine density, whereas increases in age from 8 to 14 weeks were associated with a decrease in dendritic spine density. C, analysis of spine type showed that wheel running decreased the percentage of stubby spines and tended to increase the percentage of thin spins. D, representative images for the four experimental groups assessed. Scale bar = 5 μm. ^* P < 0.05, ^** P < 0.01, ^*** P < 0.001.