Table 6.

Top scoring IPA biological functions and GO terms identified as up‐regulated in 8‐ vs. 14‐week‐old running rats

Term	Number of molecules	P value	Z score/ Q value
IPA
Top physiological system development and functions
Nervous system development and function	135	4.71 × 10–3 to 2.14 × 10–10	NA
Tissue development	139	4.44 × 10–3 to 2.14 × 10–10	NA
Behaviour	70	3.04 × 10–3 to 9.19 × 10–8	NA
Top nervous system development and function categories
Neuritogenesis	43	9.64 × 10–10	2.258
Development of neurons	53	2.14 × 10–10	2.201
Morphogenesis of neurons	29	1.00 × 10–6	2.023
Long‐term potentiation	19	6.14 × 10–6	2.004
Branching of neurites	16	5.63 × 10–4	1.748
Select activated canonical pathways associated with nervous system development and function
CREB signalling in neurons	10	0.003	2.121
Dopamine‐DARPP32 feedback in cAMP signalling	7	0.04	0.816
cAMP‐mediated signalling	11	0.006	0.302
GO
Top biological processes
GO:0007268–synaptic transmission	20	6.6 × 10–5	1.0 × 10–3
GO:0019226–transmission of nerve impulse	20	7.1 × 10–6	6.0 × 10–3
GO:0007267–cell‐cell signalling	23	4.9 × 10–4	1.5 × 10–1
Top cellular components
GO:0044459–plasma membrane part	62	1.9 × 10–5	5.1 × 10–3
GO:0045202–synapse	18	8.9 × 10–5	7.9 × 10–3
GO:0030054–cell junction	22	1.4 × 10–4	9.6 × 10–3
Top molecular functions
GO:0000287–magnesium ion binding	17	4.4 × 10–3	8.9 × 10–1
GO:0046873–metal ion transmembrane transporter activity	13	1.0 × 10–2	9.2 × 10–1
GO:0009055–electron carrier activity	10	1.2 × 10–2	8.6 × 10–1

For IPA generated data, the Z score is used to reflect the predicted activation state of a given network or pathway. For GO generated data, the far right column displays Q values. For GO terms, only terms inclusive of at least 10 molecules per function were included in for analysis. NA, not applicable.