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. 2016 Dec 1;6(12):2755–2771.

Figure 4.

Figure 4

PIM1 shRNA impairs the pro-growth effect of miR-370 inhibitor in ESCC cells. A. PIM1 expression is suppressed by targeted shRNA. B. Knockdown of PIM1 in cells transfected with miR-370 inhibitor results in loss of cell viability. C. Knockdown of PIM1 in cells transfected with miR-370 inhibitor leads to growth inhibition. D. Knockdown of PIM1 in cells transfected with miR-370 inhibitor results in increased apoptosis. E. Knockdown of PIM1 in cells transfected with miR-370 inhibitor results in caspase-3 activation. **P<0.01.