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. 2016 Dec 1;6(12):2755–2771.

Figure 7.

Figure 7

AIF upregulates miR-370 and represses the expression of PIM1. A. AIF dose-dependently increases the expression level of miR-370. B. AIF dose-dependently suppresses the mRNA level of PIM1. C. AIF dose-dependently represses the protein level of PIM1. D. MiR-370 inhibitor or PIM1 overexpression attenuates the anti-proliferative effect of AIF. E. MiR-370 inhibitor or PIM1 overexpression significantly abrogates the anti-growth effect of AIF. F. MiR-370 inhibitor or PIM1 overexpression compromises the apoptosis-inducing effect of AIF. G. MiR-370 inhibitor or PIM1 overexpression impairs the suppressing effect of AIF on invasion. **P<0.01.