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A, B. Effects of HDIs and CDDP on caspase-3 activation in A549 cells. Induction of apoptosis by SAHA or VPA and CDDP in concentrations 1.4 (70% IC50) and 2.4 (120% IC50) alone or in combinations after 48 h exposure. Data was analyzed by flow cytometry and results are expressed as mean ± SD of three separate experiments (n = 6 per concentration, **P<0.01, ***P<0.001 versus the control, one-way ANOVA test).
