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Mitochondria mediate the physcion-inducing apoptosis in HCC cells. A. Physcion treatment results in dose-pendent increase in caspase-9 activity while does not affect the activity of caspase-8. B. Cleaved caspase-9 level is elevated in cells treated by physcion. C. Loss of mitochondrial membrane potential is observed in cells treated with physcion. D. Release of cytochrome C from mitochondria to cytosol is found in cells treated with physcion. **P<0.01.
