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. 2016 Dec 1;6(12):2919–2931.

Figure 5.

Figure 5

Physcion modulates the level of miR-370 through AMPK/Sp1/DNMT1 signaling. A. Physcion represses the expression of DNMT1 at both mRNA and protein level. B. Physcion dose-dependently suppresses the protein level of Sp1. C. Physcion activates AMPK in dose-dependent manner. D. Physcion suppresses Sp1 expression by activating AMPK. E. AMPK/Sp1 signaling mediates the repressing effect of physcion on DNMT1. F. Physcion modulates miR-370 level through AMPK/Sp1/DNMT1 signaling. G. AMPK/Sp1/DNMT1 signaling is involved in physcion-induced apoptosis of HCC cells. **P<0.01.