Fig. 2.

FGF21 and its association with oxidative stress. Metabolic diseases, such as obesity, hyperglycemia, insulin resistance, dyslipidemia, and metabolic syndrome are in both-ways involved with the presence of endoplasmic reticulum stress and oxidative stress. Oxidative stress leads to inflammation responses that result in apoptosis and other pathologies like cardiovascular diseases and cancer. FGF21 inhibits inflammation in response to oxidative stress.