Table 2.
Signaling network and biological pathways (IPA; DAVID) generated by blood transcriptome of patients versus controls.
| Top canonical pathways (IPA) | p-Value | |
| Pyridoxal 5′-phosphate salvage pathway | 0.00187 | |
| Salvage pathways of pyrimidine ribonucleotides | 0.00407 | |
| Atherosclerosis signaling | 0.00522 | |
| Molecular and cellular functions (IPA) | Genes, n | p-Value |
| Cellular growth and proliferation | 13 | 0.0000471–0.0224 |
| Cellular function and maintenance | 12 | 0.0000150–0.0241 |
| Cellular movement | 11 | 0.0000041–0.0249 |
| Physiological system development and function (IPA) | Genes, n | p-Value |
| Hematological system development and function | 11 | 0.0000018–0.0249 |
| Tissue development | 11 | 0.0000649–0.0241 |
| Immune cell trafficking | 10 | 0.0000018–0.0249 |
| Biological processes (DAVID) | Genes, n | p-Value |
| Response to external stimulus | 8 | 0.00456 |
| Intracellular signal transduction | 8 | 0.0121 |
| Regulation of molecular function | 8 | 0.0177 |
| Cellular components (DAVID) | Genes, n | p-Value |
| Extracellular region part | 12 | 0.000528 |
| Extracellular region | 12 | 0.00261 |
| Extracellular exosome | 11 | 0.000180 |
| Molecular functions (DAVID) | Genes, n | p-Value |
| Enzyme binding | 6 | 0.0299 |
| Carbohydrate derivative binding | 6 | 0.0704 |
| Protein serine/threonine kinase activity | 3 | 0.0790 |