Fig. 5.

Differences in macrophage staining and cytidine deaminase (CDA) expression among treatment groups. Graphs depicting the number of tumor associated macrophages (TAMs; A,C) and cells with CDA expression (B,D) per µm² in the complete tumor area of SW-1990 (A,B) or MIA PaCa-2 (C,D) mice 24 h after the administration of placebo, lurbinectedin (PM01183, 0.180 mg kg⁻¹), gemcitabine (180.0 mg kg⁻¹) or the combination (PM01183 plus gemcitabine, 0.180 mg kg⁻¹+180.0 mg kg⁻¹) as assessed by immunohistochemical staining. See representative images in Fig. 4. Statistically significant differences at *P<0.01 (two-tailed Mann–Whitney U-test).