Fig. 6.
Tumor response to treatment in athymic nude mice bearing PDA-AVATAR xenografts. Mice bearing Panc-026, Panc-265, Panc-354, Panc-291, JH-010 or JH-024 tumors were treated with placebo, lurbinectedin (PM01183, 0.180 mg kg−1) or gemcitabine (180.0 mg kg−1) on days 0, 7, 14, 21 and 28. Treatment-induced antitumor activity was determined by the relative ΔT/ΔC (%), defined as the percentage of change in tumor size for treated (T) and placebo (C) groups in each experiment. Also, complete tumor regressions (CR) were defined when two or more consecutive tumor measurements were smaller than 63 mm3. DPC4, MADH4/SMAD4 gene.