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. 2016 Dec 1;9(12):1497–1506. doi: 10.1242/dmm.027326

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© 2016. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — ¹²⁴I-DPA-713 PET/CT imaging demonstrates tracer uptake localizing to the TB lesion. (A) Three-dimensional reconstruction, transverse, coronal and sagittal views of co-registered PET/CT images and gross pathology from representative M. tuberculosis-infected animal at 21 days post-infection and 24 h post-tracer injection. Gross pathology shows a discrete TB lesion in right hemisphere (blue arrow), and PET signal localizes to the TB lesion (yellow arrow) and the site of injection (ear vein, red arrow). (B) Three-dimensional reconstruction, transverse, coronal and sagittal views of co-registered PET/CT images and gross pathology from representative control animals at same time point. Gross pathology shows no lesions in the control animal, with minimal PET signal at the site of injection (red arrow). (C) Quantification of the PET signal demonstrates significant higher activity in M. tuberculosis-infected versus controls animals at 24 h post-tracer injection. M. tuberculosis-infected SUV mean±s.e.m.=0.70±0.09, n=4; control SUV mean±s.e.m.=0.25±0.02, n=2; unpaired t-test, *P=0.03. He, heart.