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. 2016 Oct 28;5(12):1821–1833. doi: 10.1242/bio.020891

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© 2016. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 5. — In vivo validation of genes repressed in RA-treated NMPs. Shown are whole-mount in situ hybridization results to detect mRNA in E8.0-E8.5 wild-type (WT) and Raldh2^−/− (−/−) RA-deficient mouse embryos. Analyzed here are two genes that were found by RNA-seq to be repressed by treatment of NMPs with 25 nM RA: (A,B) Id1, (C) Fst; n=3 embryos examined for each gene. Arrows indicate the location of transverse sections through the posterior neural tube; arrowheads indicate the location of transverse sections through the caudal epiblast; numbered panels to right refer to corresponding sections. CLE, caudal lateral epiblast; LPM, lateral plate mesoderm; NT, neural tube; PS, primitive streak; PSM, presomitic mesoderm; S, somite.