Table 1.

Main biological databases for hematology research

Name	Weblink	Main features	Cell type	Data type	Refs.
European LeukemiaNet	http://www.leukemia-net.org/content/home/index_eng.html	Providing physicians and patients research information about diagnosis, treatment, and ongoing clinical trials, as well as further information about leukemia	Clinical data of leukemia patients	Clinical data	[8]
Red Cell Membrane Disorder Mutations Database	http://research.nhgri.nih.gov/RBCmembrane	Grouping all mutation genes occurring in single or more kinds of inherited disorders of the erythrocyte membrane associated with hemolytic anemia	RBCs of hereditary spherocytosis, hereditary elliptocytosis, and hereditary pyropoikilocytosis patients	Mutation information of related genes	[9]
dbRBC	http://www.ncbi.nlm.nih.gov/projects/gv/rbc/main.fcgi?cmd=nit	Providing DNA and clinical data related to the human RBCs, integrated with BGMUT database documenting variations in genes that encode antigens for human blood groups	Human RBCs	DNA and clinical data	[10]
CODEX	http://codex.stemcells.cam.ac.uk	Containing a subunit database HAEMCODE specialized for grouping NGS data of human and mouse hematopoietic cell experiments	Human and mouse hematopoietic cells	NGS data	[12]
ErythronDB	http://www.cbil.upenn.edu/ErythronDB	Providing expression profile of murine primitive and definitive erythroid cells, and supporting gene searching with annotation, differential expression, transcriptional regulation, etc.	Murine primitive and definitive erythroid cells	Gene expression data	[13]
Hembase	http://hembase.niddk.nih.gov/	Integrating sequencing data of ESTs of human erythroid cells, differentiated erythrocytes, and mature RBCs	Human erythroid cells, differentiated erythrocytes, and mature RBCs	EST data	[1]
BloodSpot	http://www.bloodspot.eu	Providing gene expression profiles of healthy and malignant hematopoiesis in human or mice, encompassing more than 5000 samples in total	Human or mouse hematopoietic cells	Oligonucleotide microarray chip data and RNA-seq data	[15]
BloodChIP	http://www.med.unsw.edu.au/CRCWeb.nsf/page/BloodChIP	Exploring and visualizing TF sites in human CD34+ and other normal and leukemic cells based on TF ChIP-seq data	Human CD34+ and leukemic cells	Gene expression data, histone ChIP-seq data, DNase-seq data, and digital genomic footprinting data	[17]
Leukemia Gene Atlas	http://www.leukemia-gene-atlas.org/LGAtlas	Integrating datasets from more than 5800 leukemia and hematopoiesis samples sequenced by microarray, DNA methylation, SNP, and high-throughput sequencing	Clinical leukemia samples	Microarray, DNA methylation, and SNP data	[19]
DBA mutation database	http://www.dbagenes.unito.it	Integrating information on DBA mutation genes and changes of DNA, RNA, protein, and the frequency of the mutation	Blood cells of DBA	General information on variants of all DBA-related genes	[23], [24]

Note: ErythronDB, the Erythron Database; ChIP, chromatin immunoprecipitation; EST, expressed sequence tag; DBA, Diamond-Blackfan anemia; BGMUT, Blood Group Antigen Gene Mutation Database; NGS, next-generation sequencing; RBC, red blood cell; SNP, single nucleotide polymorphism; TF, transcription factor.