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. 2016 Jul 26;5:1822. [Version 1] doi: 10.12688/f1000research.9094.1

PMC5200949.1; 2016 Jul 26
PMC5200949.2; 2016 Dec 7

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Copyright: © 2016 Koehn LM et al.

This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 10. — ( a) Extravasation of HRP (44 kDa) extending radially out from sites of injury at 2 h post-injury. ( b) HRP is confined to the lumen of blood vessels at 24 h post-injury with no visible leakage around sites of injury. ( c) Extensive leakage of the 10 kDa dextran rhodamine B is observed around sites of injury at 24 h post-injury. ( d) at 5 days post-injury, 10 kDa dextran rhodamine B was always confined to the lumen of blood vessels. ( e) diagrammatic summary of the period of blood-spinal cord barrier disruption after SCI vs the molecular size of the permeability tracers. The tracers; dextran fluorescein, 70 kDa DF; horseradish peroxidase, HRP 44 kDa, dextran rhodamine B (DRB 10 kDa), biotin-dextran-amine (BDA 3 kDa), biotin-ethylene-diamine (BED 0.3 kDa) were injected systemically 20 minutes prior to collection of tissue. A tick mark indicates the presence of visible tracer extravasation whereas a cross indicates that the tracers were confined to the lumen of blood vessels.