Table 4.
Associations between SORL1 rs1784933 and cognitive tests
| Subjects | Cognitive tests | SORL1 rs1784933 | p Value (ANOVA) | ||
|---|---|---|---|---|---|
| AA | AG | GG | |||
| Control subjects | MMSE score | 28.0 ± 2.1 | 28.1 ± 1.9 | 27.6 ± 2.1 | 0.490 |
| MCI | MMSE score | 25.9 ± 2.9 | 26.0 ± 2.8 | 26.7 ± 2.4 | 0.468 |
| 12-item word recall test | 4.5 ± 3.0 | 4.5 ± 2.7 | 5.0 ± 2.6 | 0.877 | |
| Forward digit span | 10.0 ± 2.8 | 10.2 ± 2.1 | 9.1 ± 2.9 | 0.507 | |
| Backward digit span | 5.5 ± 2.5 | 6.1 ± 2.1 | 6.3 ± 3.2 | 0.271 | |
| Verbal fluency test | 10.1 ± 2.8 | 10.5 ± 3.4 | 9.5 ± 2.3 | 0.576 | |
| Boston Naming Test | 13.5 ± 1.2 | 13.8 ± 1.3 | 13.4 ± 1.4 | 0.290 | |
| Trail Making Test A, seconds | 99.7 ± 67.2 | 84.1 ± 38.9 | 74.4 ± 39.0 | 0.177 | |
| AD | MMSE score | 18.1 ± 6.0 | 18.5 ± 5.7 | 18.5 ± 6.0 | 0.648 |
| 12-item word recall test | 1.3 ± 2.1 | 1.5 ± 2.2 | 1.5 ± 2.5 | 0.494 | |
| Forward digit span | 8.3 ± 3.1 | 8.6 ± 3.1 | 8.1 ± 2.2 | 0.224 | |
| Backward digit span | 3.8 ± 2.1 | 3.9 ± 2.2 | 3.5 ± 1.8 | 0.461 | |
| Verbal fluency test | 6.4 ± 3.3 | 6.5 ± 3.1 | 6.9 ± 2.8 | 0.537 | |
| Boston Naming Test | 11.2 ± 3.1 | 11.5 ± 2.9 | 11.9 ± 2.3 | 0.229 | |
| Trail Making Test A, seconds | 186.8 ± 160.5 | 175.6 ± 130.4 | 182.9 ± 115.2 | 0.630 | |
Abbreviations: AD Alzheimer’s disease, MCI Mild cognitive impairment, SORL1 Sortilin-related receptor 1 gene, MMSE Mini Mental State Examination, ANOVA One-way analysis of variance