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. 2016 Dec 1;129(23):4341–4353. doi: 10.1242/jcs.193904

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© 2016. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 7. — Model for Rab40b mediated MMP2 and MMP9 targeting to the invadopodia. Tks5 initiates invadopodia formation at PI(3,4)P₂-enriched regions of the plasma membrane and acts as a tethering factor to recruit Rab40b vesicles containing MMP2 and MMP9. The interaction between Rab40b and Tks5 allows for the release of MMP2 and MMP9 in the ECM at invadopodia. miR-204 acts as a tumor suppressor by regulating both Rab40b- and Tks5-mediated invadopodia formation and function.