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. 2016 Dec 1;143(23):4324–4340. doi: 10.1242/dev.139857

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© 2016. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 5. — AP-1 binding is required in SM and HE1 for the transient activation of genes, and is enriched at AP-1 and TEAD motifs. (A) K-means clustering of log₂ expression levels of genes associated with FOS:JUN co-bound sites. Each of the clusters (1-7) represents a specific pattern of gene expression levels. (B) Average mRNA microarray expression values of genes from clusters 1-7 as defined in B, without (black) and with (red) DOX for the different cell types of the differentiation. (C) Enriched transcription factor binding motifs in FOS-only, FOS:JUN and JUN-only peaks using HOMER de novo motif discovery analysis.