Table 3.

Multiple Logistic Regression Models for white matter lesions, with presence of 5-Year Cognitive Decline as the Outcome Variable. Those with prevalent dementia at baseline were excluded.

Models	Odds Ratios (95% CI)	P value
Model 1 unadjusted	1.95 (1.13–3.38)	0.02
Model 2	1.91 (1.06–3.44)	0.03
Model 3	1.97 (1.08–3.61)	0.03
Subgroup analysis: Excluding subjects with cognitive impairment (CASI < 74) or prevalent clinical stroke at baseline
Model 1 unadjusted	2.10 (1.05–4.19)	0.04
Model 2	2.33 (1.08–5.00)	0.03
Model 3	2.47 (1.10–5.55)	0.03
Subgroup analysis: Excluding subjects with cognitive impairment (CASI < 74) or prevalent clinical stroke at baseline or ApoE genotype positive*
Model 1 unadjusted	2.71 (1.07–6.89)	0.04
Model 2	3.90 (1.26–12.10)	0.02
Model 3	4.13 (1.22–14.00)	0.02

Model #1 unadjusted.

Model #2 adjusted for age, education, ApoE4 genotype, large or small infarcts on MRI, and baseline CASI.

Model #3 adjusted for age, education, ApoE4 genotype, large or small infarcts on MRI, baseline CASI, baseline hypertension, time of follow-up.

^*Subgroup analyses excluding men with ApoE4 genotype were not adjusted for ApoE4.

Abbreviations: CASI=cognitive abilities screening instrument.