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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Crit Care Med. 2016 Nov;44(11):e1074–e1081. doi: 10.1097/CCM.0000000000001951

Figure 4. Anti-IL-17 antibody reduces liver dysfunction in mice.

Figure 4

Mice (n=6 in all groups) were subjected to an experimental hemorrhagic shock and trauma model (HS/T) as described in the Materials and Methods. (A) Time course of circulating IL-17A/F in mice subjected to HS/T. *: P<0.05 vs. baseline which quickly diminished by 12h and 24h time points. (B and C) Neutralization of IL-17A/F by an anti-IL-17 monoclonal antibody at 6h resulted in significantly decreased plasma IL-17A/F when compared to the control group by Mann-Whitney Rank Sum test (panel B; P=0.002) and a marked decrease in alanine aminotransferase (ALT), a marker of liver dysfunction, when compared to the control group by t-test (panel C; P<0.001).