Table 3. Associations with risk of endoscopic-only Barrett’s esophagus.
Endo-only BE vs. Primary care controls | Endo-only BE vs. Endoscopy controls | ||
---|---|---|---|
AOR* (95% CI) | AOR* (95% CI) | ||
BMI | |||
<25 | 1.00 (Ref) | 1.00 (Ref) | |
25–29.9 | 0.62 (0.31–1.26) | 0.76 (0.40–1.47) | |
≥30 | 0.71 (0.37–1.37) | 1.19 (0.66–2.15) | |
WHR | |||
Tertile 1 | 1.00 (Ref) | 1.00 (Ref) | |
Tertile 2 | 0.73 (0.38–1.39) | 1.06 (0.58–1.93) | |
Tertile 3 | 1.64 (0.91–2.93) | 1.65 (0.97–2.80) | |
GERD symptoms | |||
Never | 1.00 (Ref) | 1.00 (Ref) | |
Ever | 2.25 (1.32–3.85) | 0.54 (0.32–0.89) | |
GERD duration | |||
Never | 1.00 (Ref) | 1.00 (Ref) | |
<5 yrs | 2.22 (0.21–23.2) | 0.80 (0.10–6.17) | |
5–9 yrs | 5.14 (1.08–24.5) | 1.11 (0.32–3.80) | |
≥10 yrs | 3.49 (2.07–5.91) | 1.14 (0.70–1.84) | |
Frequency of GERD and age at onset | |||
Never | 1.00 (Ref) | 1.00 (Ref) | |
≥weekly age <30y | 2.86 (0.88–9.26) | 0.44 (0.17–1.12) | |
≥weekly age 30-49y | 3.81 (1.76–8.25) | 0.64 (0.32–1.26) | |
≥weekly age 50-79y | 1.45 (0.50–4.16) | 0.30 (0.11–0.81) | |
<weekly age <30y | 1.61 (0.19–13.8) | 0.52 (0.06–4.07) | |
<weekly age 30-49y | - | - | |
<weekly age 50-79y | 1.08 (0.12–9.58) | 0.46 (0.06–3.63) | |
Smoking status | |||
Never | 1.00 (Ref) | 1.00 (Ref) | |
Ever | 0.57 (0.34–0.97) | 0.56 (0.35–0.91) | |
Alcohol status | |||
Never | 1.00 (Ref) | 1.00 (Ref) | |
Former | 1.77 (0.52–6.08) | 1.75 (0.60–5.11) | |
Current | 1.53 (0.45–5.15) | 1.92 (0.67–5.50) | |
H pylori infection | |||
No | 1.00 (Ref) | 1.00 (Ref) | |
Yes | 0.95 (0.56–1.62) | 1.05 (0.64–1.72) | |
NSAID use | |||
None | 1.00 (Ref) | 1.00 (Ref) | |
< Daily | 1.08 (0.38–3.11) | 1.27 (0.48–3.38) | |
Daily | 0.68 (0.38–1.19) | 0.81 (0.48–1.36) | |
PPI or H2RA use | |||
No | 1.00 (Ref) | 1.00 (Ref) | |
Yes | 4.44 (2.61–7.54) | 0.88 (0.53–1.44) | |
Active Gastritis | |||
No | 1.00 (Ref) | 1.00 (Ref) | |
Yes | 0.76 (0.43–1.35) | 0.95 (0.56–1.61) | |
Chronic Gastritis | |||
No | 1.00 (Ref) | 1.00 (Ref) | |
Yes | 0.99 (0.61–1.62) | 1.16 (0.74–1.82) |
Endo-only BE are those with endoscopically suspected BE in the absence of specialized intestinal metaplasia.
*Adjusted for age (<50, 50-<60, 60-<70, ≥70yrs), sex and race (white, non-white).