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. 2016 Dec 30;11(12):e0169250. doi: 10.1371/journal.pone.0169250

Table 3. Associations with risk of endoscopic-only Barrett’s esophagus.

Endo-only BE vs. Primary care controls Endo-only BE vs. Endoscopy controls
AOR* (95% CI) AOR* (95% CI)
BMI
<25 1.00 (Ref) 1.00 (Ref)
25–29.9 0.62 (0.31–1.26) 0.76 (0.40–1.47)
≥30 0.71 (0.37–1.37) 1.19 (0.66–2.15)
WHR
Tertile 1 1.00 (Ref) 1.00 (Ref)
Tertile 2 0.73 (0.38–1.39) 1.06 (0.58–1.93)
Tertile 3 1.64 (0.91–2.93) 1.65 (0.97–2.80)
GERD symptoms
Never 1.00 (Ref) 1.00 (Ref)
Ever 2.25 (1.32–3.85) 0.54 (0.32–0.89)
GERD duration
Never 1.00 (Ref) 1.00 (Ref)
<5 yrs 2.22 (0.21–23.2) 0.80 (0.10–6.17)
5–9 yrs 5.14 (1.08–24.5) 1.11 (0.32–3.80)
≥10 yrs 3.49 (2.07–5.91) 1.14 (0.70–1.84)
Frequency of GERD and age at onset
Never 1.00 (Ref) 1.00 (Ref)
≥weekly age <30y 2.86 (0.88–9.26) 0.44 (0.17–1.12)
≥weekly age 30-49y 3.81 (1.76–8.25) 0.64 (0.32–1.26)
≥weekly age 50-79y 1.45 (0.50–4.16) 0.30 (0.11–0.81)
<weekly age <30y 1.61 (0.19–13.8) 0.52 (0.06–4.07)
<weekly age 30-49y - -
<weekly age 50-79y 1.08 (0.12–9.58) 0.46 (0.06–3.63)
Smoking status
Never 1.00 (Ref) 1.00 (Ref)
Ever 0.57 (0.34–0.97) 0.56 (0.35–0.91)
Alcohol status
Never 1.00 (Ref) 1.00 (Ref)
Former 1.77 (0.52–6.08) 1.75 (0.60–5.11)
Current 1.53 (0.45–5.15) 1.92 (0.67–5.50)
H pylori infection
No 1.00 (Ref) 1.00 (Ref)
Yes 0.95 (0.56–1.62) 1.05 (0.64–1.72)
NSAID use
None 1.00 (Ref) 1.00 (Ref)
< Daily 1.08 (0.38–3.11) 1.27 (0.48–3.38)
Daily 0.68 (0.38–1.19) 0.81 (0.48–1.36)
PPI or H2RA use
No 1.00 (Ref) 1.00 (Ref)
Yes 4.44 (2.61–7.54) 0.88 (0.53–1.44)
Active Gastritis
No 1.00 (Ref) 1.00 (Ref)
Yes 0.76 (0.43–1.35) 0.95 (0.56–1.61)
Chronic Gastritis
No 1.00 (Ref) 1.00 (Ref)
Yes 0.99 (0.61–1.62) 1.16 (0.74–1.82)

Endo-only BE are those with endoscopically suspected BE in the absence of specialized intestinal metaplasia.

*Adjusted for age (<50, 50-<60, 60-<70, ≥70yrs), sex and race (white, non-white).